REVERSION: SENTENCE ANALOGIES


Consider the following frameshift mutation:

The old man saw the bad dog and ran and hid

frameshift deletion of first "w"

The old man sat heb add oga ndr ana ndh id

frameshift insertion of the letter (base equivalent) "a" 

The old man sat heb add oga and ran and hid


How can this reversion occur?

  1. Spontaneous, e.g., strand slippage
  2. Induced by a mutagen..........

The old man sat heb add oga ndr ana ndh id

intercalating agent 

The old man sat heb add ogand ran and hid


Consider the following base substitution mutation:

The old man saw the bad dog and ran and hid base-substitution mutation g --> a The old man saw the bad doa and ran and hid + 5-BU (Re: AT => GC) The old man saw the bad dog and ran and hid