An Example of Bypass Suppression

argD mutants cansuppress many different proB and proA mutants, including proBA deletion mutants. argD mutants accumulate high intracellular concentrations of Acetyl-glutamic semialdehyde (Acetyl-GSA) which can be hydrolyzed to Glutamic semialdehyde (GSA) by the argE gene product.

argD mutants can grow slowly without added arginine because other transaminases.


Kuo and Stocker. 1969. J. Bacteriol. 98: 593-598.

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