An Example of Bypass Suppression


argD mutants cansuppress many different proB and proA mutants, including proBA deletion mutants. argD mutants accumulate high intracellular concentrations of Acetyl-glutamic semialdehyde (Acetyl-GSA) which can be hydrolyzed to Glutamic semialdehyde (GSA) by the argE gene product.

argD mutants can grow slowly without added arginine because other transaminases.

REFERENCE:

Kuo and Stocker. 1969. J. Bacteriol. 98: 593-598.


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