Reversion and Suppression

• True revertants
  • True reversion

  • The Ames Test

• Suppression

  Intragenic suppressors - a second, compensating mutation within the same gene

  • Types of intragenic suppressors

  • Base changes - sentence analogies

  Intergenic suppressors - a second, compensating mutation in a different gene
  • Informational suppressors
    • tRNA suppressors

    • Nonsense suppressor mutants

    • tRNAs and anticodon wobble

    • Effect of nonsense mutations and nonsense suppressors on translation

    • An example of nonsense suppression

    • Uses of nonsense suppressors

    • How nonsense mutations got their names

    • Omnipotent suppressors

  • Bypass suppressors

  • Interaction suppressors

  • Overproduction suppressors

• Suppressor dominance

• Synthetic lethal mutations

• Some sample reversion problems
• Some sample intragenic suppression problems
• Some sample intergenic suppression problems

Please send comments, suggestions, or questions to smaloy@sciences.sdsu.edu
Last modified November 29, 2003