Eukaryotic Gene Regulation

"Thirty years ago, Jacob and Monod described how genes are selectively switched on and off in bacterial cells. According to their paradigm for gene regulation, specialized DNA sequences, later termed cis-regulatory sequences, are interpreted and mobilized by trans-acting regulatory proteins ...

Genes of eukaryotic organisms work in the same way; the names and faces have been changed to protect those of us too proud to realize that we have been busily rediscovering the wheel. Cis-regulatory DNA sequences are fashionably called enhancers and silencers; trans-acting regulatory proteins are collectively termed transcription factors."

DeLaBrousse and McKnight (1993. Trends Genetics 9: 151) as quoted by Jacob (who now studies Drosophilia)

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Last modified April 25, 2000