Transcriptional activators are proteins that bind to DNA and stimulate transcription of nearby genes. Most activators enhance RNA polymerase binding (formation of the closed complex) or the transition to the open complex required for initiation of transcription. Most activators interact directly with a subunit of RNA polymerase. Some examples follow:
SOME USEFUL GENERAL REVIEWS ON ACTIVATORS:
- Regulation of the arabinose regulation by AraC
- Catabolite repression by cAMP-CRP
- Barnard A, Wolfe A, Busby S. 2004. Regulation at complex bacterial promoters: how bacteria use different promoter organizations to produce different regulatory outcomes. Curr Opin Microbiol. 7: 102-108.
- Lloyd G, Landini P, Busby S. 2001. Activation and repression of transcription initiation in bacteria. Essays Biochem. 37: 17-31.
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Last modified October 26, 2005