Antirestriction systems

Restriction endonucleases will degrade invading double-stranded phage or plasmid DNA that is not appropriately modified. However, under certain stress conditions (for example, induction of the SOS response or heat shock) restriction endonucleases can be temporarily inactivated [Kelleher and Raleigh 1994; Barcus and Murray 1995]. Furthermore, many phage and plasmids have mechanisms to avoid degradation of their DNA. Such mechanisms are called "antirestriction systems". Some examples of antirestriction systems are described below.


For a nice recent review see:
Wilkins B. 2002.Plasmid promiscuity: meeting the challenge of DNA immigration control. Environ Microbiol. 4: 495-500.

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Last modified September 25, 2004