Investigating Evolutionary Differences Between Human and Non-Human Primate Brain Development Using Forebrain Oraganoid Models poster.
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Student: Davis Klein

Level: Undergraduate
Major: Biology
Host Mentor: Fred Gage, M.S., Ph.D.
Host Institution: The Salk Institute for Biological Studies – LOGG, Salk Institute
Date: 2021



As part of a large study to elucidate the evolutionary differences in brain development between humans and non-human primates, Davis Klein was seeking to develop 3D brain-like structures called brain organoids from human embryonic and induced pluripotent stem cells (iPSC) and compared them to organoids generated from four different primate iPSC lines. Davis was involved in the project through stem cell maintenance, brain organoid generation and maintenance, and immunohistochemical analysis. He also participated in MEA and growth rate data collection and analysis, literature searches, and data presentations.

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