Recommended Texts

READINGS FOR

BIOETHICS IN MOLECULAR LIFE SCIENCES

Molecular Biology 610 – Fall 2009

Sanford Bernstein

Course Texts

Baruch A. Brody The Ethics of Biomedical Research, An International Perspective; Oxford University Press, 1998
On Being a Scientist, Responsible Conduct in Research; National Academy Press, 2009

Reading assignments

Required reading denoted by **

Aug 31

An introduction to bioethics and research ethics

Sanford Bernstein, Ph.D., SDSU Biology (sbernst@sunstroke.sdsu.edu)

**Brody Chapter 10

Bernstein Introductory Lecture (PDF)

Sept 2

Philosophical underpinnings of bioethics

Darrel Moellendorf, Ph.D., SDSU Philosophy (dmoellen@mail.sdsu.edu)

**Brody Chapter 10

Authorship issues; Plagiarism and falsification of scientific data; Ownership of scientific data

Sanford Bernstein, Ph.D., SDSU Biology (sbernst@sunstroke.sdsu.edu)

**NAS Booklet

**Article on scientific plagiarism (PDF)

** Another article on plagiarism for which you are to write a 1 paragraph (one page or less) summary. Due September 9^th. No plagiarism! http://arstechnica.com/old/content/2007/08/plagiarism-and-falsified-data-slip-into-the-scientific-literature.ars

** Article on difficulties encountered by whistleblowers (PDF)

Office of Integrity Plagiarism Paper (PDF)

Bernstein Scientific Integrity Lecture (PDF)

Sept 9

Patenting molecules, devices and organisms

Michael Rondelli, J.D., Director, SDSU Research Foundation Technology Transfer Office (mrondelli@foundation.sdsu.edu)

Rondelli Patenting Lecture (PDF)

Sept 14

Dealing with animals in an ethical manner

Kent Osborn, DVM, Ph.D., UCSD (kosborn@acp.ucsd.edu)

**Brody Chapter 1

**NASA Principles for the Ethical Care and Use of Animals (Click here for PDF file)

** (Introduction and Chapter 1): National Research Council. Guide for the Care and Use of Laboratory Animals, National Academy Press, 1996. http://www.nap.edu/catalog.php?record_id=5140

**US Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. http://grants.nih.gov/grants/olaw/references/phspol.htm#USGovPrinciples

National Research Council. Use of Laboratory Animals in Biomedicaland Behavioral Research. National Academy Press, 1988. http://www.nap.edu/books/0309038391/html/

Animal Testing Battle Focuses Anew On Apes

Animalistic Behavior Against Novartis

European Union continues phasing out animal experiments

When animal rights activists attack

Field research: The animal protectionist view. http://norecopa.info/norecopa/vedlegg/30Krag.pdf

Once quiet scientist

Osborn Animal Ethics Lecture

Sept 16

Animal cloning and genetic engineering

Oliver Ryder, Ph.D. Conservation & Research for Endangered Species, Zoological Society of San Diego (oryder@ucsd.edu)

**Brody Chapter 5

**Business and Regulatory News In Brief Nature Biotechnology May 2003 21(5) 473-475 (click here for PDF file)

**Oliver A. Ryder Cloning advances and challenges for conservation Trends in Biotechnology 20(6) June 2002 (click here for PDF file)

**Oliver A. Ryder and Kurt Benirschke The potential use of "cloning" in the conservation effort Zoo Biology 16: 295-300 (1997) (click here for PDF file)

**McConkey and Varki. Thoughts on the future of great ape research. Science 309: 1499-1501 (2005). (click here for PDF file)

**Yule. Cloning the extinct: restoration as ecological prosthesis. Common Ground 1.2: 6-9 (2002). (click here for PDF file)

** Scientists Sequence Woolly-Mammoth Genome http://www.science.psu.edu/alert/SchusterMiller11-2008.htm

Sept 21

Human subjects: Controversial studies; Regulations & ethical principles; Risks vs. benefits

Camille Nebeker, Director, Division of Research Affairs, SDSU (nebeker@mail.sdsu.edu)

**Brody Chapters 2, 6, 9

**Nebeker human subjects outline (includes readings)

**Article on Polyheme

**Letter to IRBs regarding Polyheme

Sept 28

Designing ethical pharmaceutical studies; Informed consent; Pharmacogenomic testing

Joe Tami, Pharm. D., Director of Scientific Affairs, Therapeutics Incorporated (jtami@therapeuticsinc.com)

**Brody Chapters 7, 8

**Article on sham procedures PDF

**A series of articles regarding proper informed consent and investigator ethics involving a clinical trial at one of the top bone marrow transplant centers: http://seattletimes.nwsource.com/uninformed_consent/

** A series of articles entitled “Drug researchers leak secrets to Wall Street”: http://seattletimes.nwsource.com/news/business/drugsecrets/

Note: You may have to register with the Seattle Times to access their web site (free).

Links to New England Journal of Medicine articles regarding a Phase I trial:

http://content.nejm.org/cgi/reprint/355/10/1060.pdf

http://content.nejm.org/cgi/reprint/355/10/1018.pdf

Sept 30

Human stem cells and cloning

Mary Devereaux, Ph.D. Mary Devereaux, Ph.D., Research Ethics Program, UCSD (mdevereaux@ucsd.edu)

**Brody Chapter 5

**ISSCR Guidlines

**Wainwright stem cell ethics

Devereaux stem cell lecture

Oct 5

Gene delivery and therapy

Theodore Friedmann, M.D., UCSD School of Medicine (tfriedmann@ucsd.edu)

**Brody Chapter 4

**The Nuremberg Code (http://www.hhs.gov/ohrp/references/nurcode.htm)

**World Medical Association Declaration of Helsinki --- Ethical Principles for Medical Research Involving Human Subjects (http://www.wma.net/e/policy/b3.htm)

Induced pluripotent stem cells-Nature

Induced pluripotent stem cells-Cell Stem Cell

**Friedmann stem cells/gene therapy article

Oct 7

Ethics of Agricultural Biotechnology

Alan McHughen, Ph.D., Botany and Plant Sciences, UC Riverside (alan.mchughen@ucr.edu)

** Agricultural Ethics (PDF)

Oct 19

Biological warfare

Roger Sabbadini, Ph.D., Institute for International Security and Conflict Resolution, SDSU (rsabba@sunstroke.sdsu.edu)

** CRS report (PDF)

** Kasper dual use report (PDF)