READINGS FOR
BIOETHICS IN MOLECULAR LIFE SCIENCES
Molecular Biology 610 – Fall
2009
Sanford Bernstein
Course Texts
Reading assignments
Required reading denoted by **
An introduction to bioethics and
research ethics
Sanford Bernstein, Ph.D., SDSU
Biology (sbernst@sunstroke.sdsu.edu)
**Brody Chapter 10
Bernstein
Introductory Lecture (PDF)
Sept 2
Philosophical underpinnings of
bioethics
Darrel Moellendorf, Ph.D., SDSU
Philosophy (dmoellen@mail.sdsu.edu)
**Brody Chapter 10
Authorship issues; Plagiarism
and falsification of scientific data; Ownership of scientific data
Sanford Bernstein, Ph.D., SDSU
Biology (sbernst@sunstroke.sdsu.edu)
**NAS Booklet
**Article
on scientific plagiarism (PDF)
** Another article on plagiarism for which you are to write a 1 paragraph
(one page or less) summary. Due September 9th. No plagiarism! http://arstechnica.com/old/content/2007/08/plagiarism-and-falsified-data-slip-into-the-scientific-literature.ars
** Article
on difficulties encountered by whistleblowers (PDF)
Office
of Integrity Plagiarism Paper (PDF)
Bernstein
Scientific Integrity Lecture (PDF)
Sept 9
Patenting molecules, devices and
organisms
Michael Rondelli, J.D., Director,
SDSU Research Foundation Technology Transfer Office (mrondelli@foundation.sdsu.edu)
Rondelli
Patenting Lecture (PDF)
Sept 14
Dealing with animals in an
ethical manner
Kent Osborn, DVM, Ph.D., UCSD (kosborn@acp.ucsd.edu)
**Brody Chapter 1
**NASA Principles for the Ethical
Care and Use of Animals (Click
here for PDF file)
** (Introduction and Chapter 1): National Research Council. Guide for the
Care and Use of Laboratory Animals, National Academy Press, 1996. http://www.nap.edu/catalog.php?record_id=5140
**US Government Principles for the Utilization and Care of Vertebrate
Animals Used in Testing, Research, and Training. http://grants.nih.gov/grants/olaw/references/phspol.htm#USGovPrinciples
National Research Council. Use of Laboratory Animals in Biomedicaland
Behavioral Research. National Academy Press, 1988. http://www.nap.edu/books/0309038391/html/
Animal
Testing Battle Focuses Anew On Apes
Animalistic
Behavior Against Novartis
European
Union continues phasing out animal experiments
When
animal rights activists attack
Field research: The animal protectionist view. http://norecopa.info/norecopa/vedlegg/30Krag.pdf
Sept 16
Animal cloning and genetic
engineering
Oliver Ryder, Ph.D. Conservation
& Research for Endangered Species, Zoological Society of San Diego (oryder@ucsd.edu)
**Brody Chapter 5
**Business and Regulatory News In
Brief Nature Biotechnology May 2003 21(5) 473-475 (click
here for PDF file)
**Oliver A. Ryder Cloning advances
and challenges for conservation Trends in Biotechnology 20(6) June 2002 (click
here for PDF file)
**Oliver A. Ryder and Kurt
Benirschke The potential use of "cloning" in the conservation effort
Zoo Biology 16: 295-300 (1997) (click
here for PDF file)
**McConkey and Varki. Thoughts on the future of great ape research. Science
309: 1499-1501 (2005). (click
here for PDF file)
**Yule. Cloning the extinct: restoration as ecological prosthesis. Common
Ground 1.2: 6-9 (2002). (click
here for PDF file)
** Scientists Sequence
Woolly-Mammoth Genome http://www.science.psu.edu/alert/SchusterMiller11-2008.htm
Sept 21
Human subjects: Controversial
studies; Regulations & ethical principles; Risks vs. benefits
Camille Nebeker, Director, Division
of Research Affairs, SDSU (nebeker@mail.sdsu.edu)
**Brody Chapters 2, 6, 9
**Nebeker
human subjects outline (includes readings)
**Letter
to IRBs regarding Polyheme
Sept 28
Designing ethical pharmaceutical
studies; Informed consent; Pharmacogenomic testing
Joe Tami, Pharm. D., Director of
Scientific Affairs, Therapeutics Incorporated (jtami@therapeuticsinc.com)
**Brody Chapters 7, 8
**Article on sham procedures PDF
**A series of articles regarding proper informed consent and investigator ethics involving a clinical trial at one of the top bone marrow transplant centers: http://seattletimes.nwsource.com/uninformed_consent/
** A series of articles entitled “Drug researchers leak secrets to Wall Street”: http://seattletimes.nwsource.com/news/business/drugsecrets/
Note: You may have to register with the Seattle Times to access their web site (free).
Links to New England Journal of Medicine articles regarding a Phase I trial:
http://content.nejm.org/cgi/reprint/355/10/1060.pdf
http://content.nejm.org/cgi/reprint/355/10/1018.pdf
Sept 30
Human stem cells and cloning
Mary Devereaux, Ph.D. Mary
Devereaux, Ph.D., Research Ethics Program, UCSD (mdevereaux@ucsd.edu)
**Brody Chapter 5
Oct 5
Gene delivery and therapy
Theodore Friedmann, M.D., UCSD
School of Medicine (tfriedmann@ucsd.edu)
**Brody Chapter 4
**The Nuremberg Code (http://www.hhs.gov/ohrp/references/nurcode.htm)
**World Medical Association Declaration of Helsinki --- Ethical Principles
for Medical Research Involving Human Subjects (http://www.wma.net/e/policy/b3.htm)
Induced
pluripotent stem cells-Nature
Induced
pluripotent stem cells-Cell Stem Cell
**Friedmann
stem cells/gene therapy article
Oct 7
Ethics of Agricultural
Biotechnology
Alan McHughen, Ph.D., Botany and
Plant Sciences, UC Riverside (alan.mchughen@ucr.edu)
** Agricultural Ethics (PDF)
Oct 19
Biological warfare
Roger Sabbadini, Ph.D., Institute
for International Security and Conflict Resolution, SDSU (rsabba@sunstroke.sdsu.edu)
** CRS report (PDF)
** Kasper dual use report (PDF)
Sabbadini
biological warfare lecture