READINGS FOR

BIOETHICS IN MOLECULAR LIFE SCIENCES

Molecular Biology 610 – Fall 2007

Sanford Bernstein

 

Course Texts

 

Reading assignments

Required reading denoted by **

 

Aug 27

Bioethics: perspectives of a scientist and of a philosopher

Sanford Bernstein, Ph.D. SDSU Biology (sbernst@sunstroke.sdsu.edu)

Darrel Moellendorf, Ph.D. SDSU Institute for Ethics & Public Affairs (dmoellen@mail.sdsu.edu)

**Brody Chapter 10

Bernstein: Bioethics Introduction (PDF)

Moellendorf: Four Principles of Bioethics (PDF)

 

Aug 29

Authorship issues; Plagiarism and falsification of scientific data; Ownership of scientific data

Sanford Bernstein, Ph.D. SDSU Biology (sbernst@sunstroke.sdsu.edu)

**NAS Booklet

 **Article on scientific plagiarism (PDF)

** Article on difficulties encountered by whistleblowers (PDF)

Bernstein: Scientific Integrity (PDF)

 

Sept 5

Patenting molecules, devices and organisms

Michael Rondelli, Program Manager, SDSU Research Foundation Technology Transfer Office (mrondelli@foundation.sdsu.edu)

Rondelli: Powerpoint Presentation (PDF)

Article on Merck vs. Integra

Article on Biotech Patent Laws

 

Sept 10

Dealing with animals in an ethical manner

Kent Osborn, DVM, PhD, The Scripps Research Institute (kgosb@scripps.edu)

**Brody Chapter 1

**NASA Principles for the Ethical Care and Use of Animals (Click here for PDF file)

National Research Council. Guide for the Care and Use of Laboratory Animals, National Academy Press, 1996. http://www.nap.edu/readingroom/books/labrats/

National Research Council. Use of Laboratory Animals in Biomedicaland Behavioral Research. National Academy Press, 1988. http://www.nap.edu/books/0309038391/html/ 

U.S. GOVERNMENT PRINCIPLES FOR UTILIZATION AND CARE OF VERTEBRATE ANIMALS USED IN TESTING, RESEARCH AND TRAINING (PDF)

Osborn: Powerpoint Presentation (PDF)

Osborn: Notes (PDF)

 

Sept 12

Designing ethical pharmaceutical studies; Informed consent; Pharmacogenomic testing

Joe Tami, Pharm. D., Director of Scientific Affairs, Therapeutics Incorporated (jtami@therapeuticsinc.com)

**Article on sham procedures PDF

**A series of articles regarding proper informed consent and investigator ethics involving a clinical trial at one of the top bone marrow transplant centers: http://seattletimes.nwsource.com/uninformed_consent/

 ** A series of articles entitled “Drug researchers leak secrets to Wall Street”: http://seattletimes.nwsource.com/news/business/drugsecrets/

 Note: You may have to register with the Seattle Times to access their web site (free).

Links to New England Journal of Medicine articles regarding a Phase I trial:

http://content.nejm.org/cgi/reprint/355/10/1060.pdf

http://content.nejm.org/cgi/reprint/355/10/1018.pdf

Tami Powerpoint Presentation (PDF)

 

Sept 17

Human stem cells and cloning

Mary Devereaux, Ph.D.  Research Ethics Program, UCSD (mdevereaux@ucsd.edu)

**Brody Chapter 5

 Articles/websites

**1. This link (http://www.ethicscenter.net/Resources/index.html) provides some items of interest. Also look at the President's Council on Bioethics Report (http://bioethics.gov/topics/stemcells_index.html ).

 

**2. Short overview article: A Technical Fix for an Ethical Bind? 24 December 2004  Vol. 306 Science. PDF

 

** 3. International Society for Stem Cell Research link (http://www.isscr.org/public/ethics.htm) to Louis Guenin, "The Ethics of Human Embryonic Stem Cell Research."

 

4. Philosophical articles for and against

 

F.M. Kamm.  Embryonic stem cell research: A moral defence.  Boston Review. Oct/Nov. 2002.  http://bostonreview.net/BR27.5/kamm.html

 

Condic and Condic.  Defining Organisms by Organization." National  Catholic Bioethics Quarterly. Summer 2005. (http://www.ncbcenter.org/ncbq.asp) You will have to register (from an SDSU domain) to read this article.

 

Devereaux Powerpoint Presentation (PDF)

 

Sept 19

Animal cloning and genetic engineering

Oliver Ryder, Ph.D. Center for Reproduction of Endangered Species, Zoological Society of San Diego (oryder@ucsd.edu)

**Brody Chapter 5

Cloning Ethics

**Business and Regulatory News In Brief Nature Biotechnology May 2003 21(5) 473-475 (click here for PDF file)

**Oliver A. Ryder Cloning advances and challenges for conservation Trends in Biotechnology 20(6) June 2002 (click here for PDF file)

**Oliver A. Ryder and Kurt Benirschke The potential use of "cloning" in the conservation effort Zoo Biology 16: 295-300 (1997) (click here for PDF file)

**McConkey and Varki. Thoughts on the future of great ape research. Science 309: 1499-1501 (2005). (click here for PDF file)

**Yule. Cloning the extinct: restoration as ecological prosthesis. Common Ground 1.2: 6-9 (2002). (click here for PDF file)

 

Sept 24

Human subjects: Controversial studies; Regulations & ethical principles;  risks vs. benefits

Gayle Simon, M.P.H., Regulatory Compliance Analyst/Educator, Graduate & Research Affairs, SDSU (gsimon@projects.sdsu.edu)

**Brody Chapters 2, 6, 9 

**1. The Belmont Report available online from the Office of Human Research Protections website: http://www.hhs.gov/ohrp/belmontArchive.html

**2. Bozeman, B. & Hirsch, P., “Science ethics as a bureaucratic problem: IRBs, Rules and Failures of Control.” Policy Sciences (2005) Vol: 38, Iss: 4:  pg: 269-291.  (PDF)

3.  Beecher, H.K., “Ethics and clinical research.” The New England journal of medicine (1966) Vol:274, Iss.:24 pg: 1354-1360. (PDF)

4. The Nuremberg Code of Ethics available online from the National Institutes of Health, Office of Human Subjects Research: http://ohsr.od.nih.gov/guidelines/nuremberg.html

Simon Powerpoint Presentation (PDF)

 

Oct 1

Gene delivery and therapy

Theodore Friedmann, M.D., UCSD School of Medicine (tfriedmann@ucsd.edu)

**Brody Chapter 4

The Nuremberg Code (http://www.dallasnw.quik.com/cyberella/Anthrax/Nuremberg.htm)

World Medical Association Declaration of Helsinki --- Ethical Principles for Medical Research Involving Human Subjects (http://www.wits.ac.za/bioethics/helsinki.htm)

 

Oct 3

Biological warfare

Roger Sabbadini, Ph.D., Institute for International Security and Conflict Resolution, SDSU (rsabba@sunstroke.sdsu.edu)

National Academy of Sciences website on biological threats and terrorism

NAS 2003 report (PDF)

NRC 2004 report (PDF)

**Mock and Fouet. Anthax. Ann. Rev. Microbiology. 2001(click here for PDF file)

**Monastersky. Publish and Perish. Chron. Higher Ed. 2002 (click here for PDF file)

**Eileen Choffnes. Bioweapons: New Labs, More Terror Bulletin of the Atomic Scientists. 2002 (click here for PDF file)

The Chemical and Biological Warfare Threat (click here for PDF file)

Biological Warfare: A Tutorial (click here for PDF file)

Sabbadini Powerpoint Presentation (PDF)

 

Oct 10

Ethics of Agricultural Biotechnology

Alan McHughen, Ph.D., Botany and Plant Sciences, UC Riverside (alan.mchughen@ucr.edu )

** Agricultural Ethics (PDF)

 

 

 

 

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