READINGS FOR
BIOETHICS IN MOLECULAR LIFE SCIENCES
Molecular Biology 610 – Fall
2007
Sanford Bernstein
Course Texts
Reading assignments
Required reading denoted by **
Bioethics: perspectives of a
scientist and of a philosopher
Sanford Bernstein, Ph.D. SDSU
Biology (sbernst@sunstroke.sdsu.edu)
Darrel Moellendorf, Ph.D. SDSU
Institute for Ethics & Public Affairs (dmoellen@mail.sdsu.edu)
**Brody Chapter 10
Bernstein:
Bioethics Introduction (PDF)
Moellendorf:
Four Principles of Bioethics (PDF)
Aug 29
Authorship issues; Plagiarism
and falsification of scientific data; Ownership of scientific data
Sanford Bernstein, Ph.D. SDSU
Biology (sbernst@sunstroke.sdsu.edu)
**NAS Booklet
**Article
on scientific plagiarism (PDF)
** Article
on difficulties encountered by whistleblowers (PDF)
Bernstein:
Scientific Integrity (PDF)
Sept 5
Patenting molecules, devices and
organisms
Michael Rondelli, Program Manager,
SDSU Research Foundation Technology Transfer Office (mrondelli@foundation.sdsu.edu)
Rondelli:
Powerpoint Presentation (PDF)
Article
on Biotech Patent Laws
Sept 10
Dealing with animals in an
ethical manner
Kent Osborn, DVM, PhD, The Scripps
Research Institute (kgosb@scripps.edu)
**Brody Chapter 1
**NASA Principles for the Ethical Care
and Use of Animals (Click
here for PDF file)
National Research Council. Guide for the Care and Use of Laboratory Animals,
National Academy Press, 1996. http://www.nap.edu/readingroom/books/labrats/
National Research Council. Use of Laboratory Animals in Biomedicaland
Behavioral Research. National Academy Press, 1988. http://www.nap.edu/books/0309038391/html/
Osborn:
Powerpoint Presentation (PDF)
Osborn:
Notes (PDF)
Sept 12
Designing ethical pharmaceutical
studies; Informed consent; Pharmacogenomic testing
Joe Tami, Pharm. D., Director of
Scientific Affairs, Therapeutics Incorporated (jtami@therapeuticsinc.com)
**Article on sham procedures PDF
**A series of articles regarding proper informed consent and investigator ethics involving a clinical trial at one of the top bone marrow transplant centers: http://seattletimes.nwsource.com/uninformed_consent/
** A series of articles entitled “Drug researchers leak secrets to Wall Street”: http://seattletimes.nwsource.com/news/business/drugsecrets/
Note: You may have to register with the Seattle Times to access their web site (free).
Links to New England Journal of Medicine articles regarding a Phase I trial:
http://content.nejm.org/cgi/reprint/355/10/1060.pdf
http://content.nejm.org/cgi/reprint/355/10/1018.pdf
Tami Powerpoint Presentation (PDF)
Sept 17
Human stem cells and cloning
Mary Devereaux, Ph.D. Research Ethics Program, UCSD (mdevereaux@ucsd.edu)
**Brody Chapter 5
Articles/websites
**1. This link (http://www.ethicscenter.net/Resources/index.html)
provides some items of interest. Also look at the President's Council on
Bioethics Report (http://bioethics.gov/topics/stemcells_index.html
).
**2. Short overview article: A Technical Fix for an Ethical
Bind? 24 December 2004 Vol. 306
Science. PDF
** 3. International Society for Stem Cell Research link (http://www.isscr.org/public/ethics.htm)
to Louis Guenin, "The Ethics of Human Embryonic Stem Cell Research."
4. Philosophical articles for and against
F.M. Kamm.
Embryonic stem cell research: A moral defence. Boston Review. Oct/Nov. 2002. http://bostonreview.net/BR27.5/kamm.html
Condic and Condic. Defining Organisms by Organization." National Catholic Bioethics Quarterly. Summer 2005. (http://www.ncbcenter.org/ncbq.asp) You will have to register (from an SDSU domain) to read this article.
Devereaux Powerpoint Presentation (PDF)
Sept 19
Animal cloning and genetic
engineering
Oliver Ryder, Ph.D. Center for
Reproduction of Endangered Species, Zoological Society of San Diego (oryder@ucsd.edu)
**Brody Chapter 5
Cloning Ethics
**Business and Regulatory News In
Brief Nature Biotechnology May 2003 21(5) 473-475 (click
here for PDF file)
**Oliver A. Ryder Cloning advances
and challenges for conservation Trends in Biotechnology 20(6) June 2002 (click
here for PDF file)
**Oliver A. Ryder and Kurt
Benirschke The potential use of "cloning" in the conservation effort
Zoo Biology 16: 295-300 (1997) (click
here for PDF file)
**McConkey and Varki. Thoughts on the future of great ape research. Science
309: 1499-1501 (2005). (click
here for PDF file)
**Yule. Cloning the extinct: restoration as ecological prosthesis. Common
Ground 1.2: 6-9 (2002). (click
here for PDF file)
Sept 24
Human subjects: Controversial
studies; Regulations & ethical principles; risks vs. benefits
Gayle Simon, M.P.H., Regulatory
Compliance Analyst/Educator, Graduate & Research Affairs, SDSU (gsimon@projects.sdsu.edu)
**Brody Chapters 2, 6, 9
**1. The Belmont Report available online from the Office of Human Research Protections website: http://www.hhs.gov/ohrp/belmontArchive.html
**2. Bozeman, B. & Hirsch, P., “Science ethics as a bureaucratic problem: IRBs, Rules and Failures of Control.” Policy Sciences (2005) Vol: 38, Iss: 4: pg: 269-291. (PDF)
3. Beecher, H.K., “Ethics and clinical research.” The New England journal of medicine (1966) Vol:274, Iss.:24 pg: 1354-1360. (PDF)
4. The Nuremberg Code of Ethics available online from the National Institutes of Health, Office of Human Subjects Research: http://ohsr.od.nih.gov/guidelines/nuremberg.html
Simon
Powerpoint Presentation (PDF)
Oct 1
Gene delivery and therapy
Theodore Friedmann, M.D., UCSD
School of Medicine (tfriedmann@ucsd.edu)
**Brody Chapter 4
The Nuremberg Code (http://www.dallasnw.quik.com/cyberella/Anthrax/Nuremberg.htm)
World Medical Association Declaration of Helsinki --- Ethical Principles for
Medical Research Involving Human Subjects (http://www.wits.ac.za/bioethics/helsinki.htm)
Oct 3
Biological warfare
Roger Sabbadini, Ph.D., Institute
for International Security and Conflict Resolution, SDSU (rsabba@sunstroke.sdsu.edu)
National Academy of
Sciences website on biological threats and terrorism
**Mock and Fouet. Anthax. Ann. Rev.
Microbiology. 2001(click
here for PDF file)
**Monastersky. Publish and Perish.
Chron. Higher Ed. 2002 (click
here for PDF file)
**Eileen Choffnes. Bioweapons: New
Labs, More Terror Bulletin of the Atomic Scientists. 2002 (click
here for PDF file)
The Chemical and Biological Warfare Threat (click
here for PDF file)
Biological Warfare: A Tutorial (click
here for PDF file)
Sabbadini
Powerpoint Presentation (PDF)
Oct 10
Ethics of Agricultural
Biotechnology
Alan McHughen, Ph.D., Botany and
Plant Sciences, UC Riverside (alan.mchughen@ucr.edu )
** Agricultural Ethics (PDF)