READINGS
FOR
BIOETHICS IN MOLECULAR LIFE
SCIENCES
Molecular Biology 610 – Fall 2011
Sanford Bernstein
Course Texts
Reading assignments
Required
reading denoted by **
An introduction to bioethics and research
ethics
Sanford
Bernstein, Ph.D., SDSU Biology (sbernst@sunstroke.sdsu.edu)
Philosophical underpinnings of bioethics
Darrel
Moellendorf, Ph.D., SDSU Philosophy (dmoellen@mail.sdsu.edu)
**Brody Chapter 10
Bernstein
Introductory Lecture (PDF)
Aug 31
Authorship issues; Plagiarism and
falsification of scientific data; Ownership of scientific data
Sanford
Bernstein, Ph.D., SDSU Biology (sbernst@sunstroke.sdsu.edu)
**NAS
Booklet
**Article on scientific plagiarism (PDF)
Another article on plagiarism: http://arstechnica.com/old/content/2007/08/plagiarism-and-falsified-data-slip-into-the-scientific-literature.ars
** Article on difficulties encountered by whistleblowers (PDF)
Office of Integrity Plagiarism Paper (PDF)
Bernstein Scientific Integrity Lecture (PDF)
ASSIGNMENT: Within one week: Provide a one
paragraph summary (less than one page) of the article at the following URL: http://www.scientificamerican.com/article.cfm?id=self-plagiarism-case
Give relevant citations to the literature,
but insure there is NO plagiarism. So, it must be written in your own words.
Sept 7
Patenting molecules, devices and organisms
Michael Rondelli, J.D., Director, SDSU Research Foundation Technology Transfer Office (mrondelli@foundation.sdsu.edu)
Rondelli Patenting Lecture (PDF)
Sept 12
Dealing with animals in an ethical manner
Kent
Osborn, DVM, Ph.D., UCSD (kgosborn@ucsd.edu)
**Brody Chapter 1
**NASA Principles for the Ethical Care and Use of Animals (Click here for PDF file)
** (Introduction and Chapter 1): National Research Council. Guide for the Care and Use of Laboratory Animals, National Academy Press, 1996. http://www.nap.edu/catalog.php?record_id=5140
**US Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. http://grants.nih.gov/grants/olaw/references/phspol.htm#USGovPrinciples
National Research Council. Use of Laboratory Animals in Biomedicaland Behavioral Research. National Academy Press, 1988. http://www.nap.edu/books/0309038391/html/
Animal Testing Battle Focuses Anew On Apes
Animalistic Behavior Against Novartis
European Union continues phasing out animal experiments
When
animal rights activists attack
Field research: The animal protectionist view. http://www.norecopa.no/norecopa/vedlegg/Krag.pdf
Sept 14
Human subjects: Controversial studies;
Regulations & ethical principles; Risks vs. benefits
Dena
Plemmons, Ph.D., Director, SDSU Division of Research Affairs, Grad &
Research Affairs
**Brody Chapters 2, 6, 9
**Belmont Report click here for PDF file
Sept 19
Designing ethical pharmaceutical studies;
Informed consent; Pharmacogenomic testing
Joe Tami, Pharm. D., Director of Scientific Affairs, Therapeutics Incorporated (jtami@therapeuticsinc.com)
** Brody Chapters 7, 8
Links to New England Journal of Medicine articles regarding pharmacogenomic testing:
** http://www.nejm.org/doi/pdf/10.1056/NEJMra0907175
** http://www.nejm.org/doi/pdf/10.1056/NEJMe0911933
Sept 26
Animal cloning and genetic engineering
Oliver Ryder, Ph.D. Conservation & Research for Endangered Species, Zoological Society of San Diego (oryder@ucsd.edu)
**Induced Pluripotent Stem Cells from Endangered Species (click here for PDF file)
Sept 28
Biological warfare
Roger Sabbadini, Ph.D., Institute for International Security and Conflict Resolution, SDSU (rsabba@sunstroke.sdsu.edu)
** CRS report (PDF)
** Kasper dual use report (PDF)
Sabbadini
biological warfare lecture
Oct 3
Gene delivery and therapy
Theodore
Friedmann, M.D., UCSD School of Medicine (tfriedmann@ucsd.edu)
**Brody Chapter 4
**The Nuremberg Code (http://www.hhs.gov/ohrp/archive/nurcode.htmlhttp://www.hhs.gov/ohrp/archive/nurcode.html)
**World Medical Association Declaration of Helsinki --- Ethical Principles for Medical Research Involving Human Subjects (http://www.wma.net/en/30publications/10policies/b3/index.html)
**Friedmann stem cells/gene therapy article
Induced pluripotent stem cells-Nature
Induced
pluripotent stem cells-Cell Stem Cell
Oct 10
Human stem cells and cloning
Karl
Willert, Ph.D., Cellular & Molecular Medicine, UCSD (kwillert@ucsd.edu)
**Brody Chapter 5