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Friday 3/31/00- On Wed, 4/5/00, Roger Sabbadini will be discussing one paper on spingolipid signaling. Hard copy of that paper can be picked up from Dr. G's office. Also, Rian Craig will begin discussing NFkB; reviews relevant to her discussion are posted on the course schedule in pdf format. There are no group assignments at this time for the NFkB section; instead, we will ask the groups to discuss various NFkB issues on an unannounced basis, so be ready for anything that is in those reviews. I won't need your virtual paper abstracts next week. I want you to get some exposure to NFkB, our last topic, before you commit to topics.
Friday 3/24/00- Dr. Sabbadini would like me to assign you to the following groups to answer the following questions. You will be asked to present your answers during the last hour of this Wednesday's class.
Group 1: Andrea, Dionne-
Discus the sphingomyelin signaling cascade. What are some of the receptors/first messengers which activate it?
Group 2: Lynette, Willow-
What are some of the physiological actions of the sphingolipid signaling molecules like ceramide, sphingosine and sphingosine-1-phosphate?
Group 3: Ben, Michelle-
How do the EDG family of G protein coupled receptors couple extracellular-derived lysophosphlipid mediators/first messengers to signaling cascades?
Group 4: Amy-
What are some physiological actions of LPA and what receptors mediate LPA action?
Friday 3/24/00- Please see the schedule for an additional Review on Apoptosis in Heart Failure, and for the pdf files for the two research papers we will discuss. Also note that you can pick up copies of the reviews you will need for sphingolipid signaling from Dr. G's office. Your discussion assignments for the sphingolipid signaling session will be posted soon.
Monday 3/20/00- Dr. Sabbadini would like me to assign you to the following groups to answer the following questions. You will be asked to present your answers during the last hour of this Wednesday's class. Check the schedule for additional links and references that are relevant to Dr. Sabbadini's section on Apoptosis. You may pick up copies of those papers that have no pdf files from Dr. Sabbadini's office begining Tuesday, 3/21/00, after 9 a.m.
Group 1: Ben, Willow-
Discuss the principal ligand/receptor triggered apoptosis systems. In terms of signaling, discribe the 'adaptor protein' concept as it applies to one or more of the ligand/receptor systems that you learned about. In your discussion of the adaptor protein concept, don't describe in detail the downstream signaling events like the caspase system (this is reserved for other groups)
Group 2: Lynette, Dionne-
Discuss the cascade of caspase activation in the cytosol. What are they and how do they get activated?
Group 3: Andrea, Michelle-
Discuss the role of the mitochondria in caspase activation with particular attention to cytochrom c and the bcl family of protoncogenes
Group 4: Mike, Amy-
How do caspases communicate the 'death signal' from the cytoplasm to the nucleus and how do caspases cause DNA damage characteristic of apoptosis?
Friday 2/18/00- You'll see quite a few papers (reviews) related to the MAP kinases. You don't need to read them all, but they are all outstanding resource papers.
On Wed 2/23/00 I want to re-organize you into the following groups:
Group 1: Ben, Amy, Willow, Andrea
Group 2: Mike, Michelle, Lynette, Dionne
After we discuss the research papers, I'd like the groups to discuss the following:
Group 1: (you'll go second) MAPK crosstalk w/ GPCR signaling pathways and MAPK scaffolds
Group 2: (you'll go first) Basic introduction to the MAP kinases, including the ERKS, JNKs and p38 families, how they're stimulated, and what their functions are.
Monday 2/14/00- On Wednesday evening we will discuss two of the three remaining research papers on non-genomic actions of steroid hormones. Then, we will move onto an introduction of GPCRs (G-protein coupled receptors). Our discussion on GPCRs will focus on receptor regulation. I would like the following groups to discuss the following topics:
Group 1: Review the subtypes of adrenergic receptors, what G-proteins they couple to and what intracellular messengers are regulated by them.
Group 2: Describe the mechanisms by which a- and b-adrenergic receptors activate gene expression.
Group 3: Discuss homologous and heterologous desensitization of b-adrenergic receptors.
Tuesday
2/10/00-
I
will see you all tomorrow evening for our first class. Please refer
to the course schedule to see what we're going to be doing tomorrow.
Even though the topic looks like I will be lecturing the whole time,
I will not. This is a student/group oriented course, not a lecture
course. So, doing the assigned reading in advance would be a really
good thing, since you'll then be prepared to discuss when
asked.
For the following week, Wed 2/9/00, you see we have three reviews and three research papers that we'll be discussing.
