Bio 630 Syllabus

Biology 630 Signal Transduction
Syllabus for Spring 2000

In the following table topics and readings that are blue are "background" while
those that are red are "research papers". Some papers are linked to pdf files, when available.
Others are not available via that format and you'll have to go to the library and copy them.

To see what you have to do with the various readings, refer to the Course Description.

Date

Topic
Reading
Instructor

Feb 2 Course Organization
Introduction, Background
Nuclear Receptors Lodish "MCB" 4th ed. Ch. 20
Schenk (1999)
Whitfield et al. (1999) J. Cell. Biochem. Supp. 32/33:110-122 Glembotski

Feb 9 Nuclear Receptors
(non-genomic actions)
Watson (1999)
Verry (1999)
Funder (1999)

Tumlin et al. (1997)
Santillan & Boland (1998)
Glembotski

Feb 16 Nuclear Receptors
G-proteins Christ et al. (1999)
Benitah & Vassort (1999)
Chen et al. (1999)
Bohm (1997)
Mayor et al. (1998) Glembotski

Feb 23 G-proteins
MAP Kinases Claing (2000)
Lin (1997)
Paul (1997)
Sprague (1998)
Whitmarsh (1998)
Whitmarsh (1999)
Garrington (1999)
Ono (2000) Glembotski

Mar 1 MAP Kinases Luttrell (1999)
Whitmarsh (JIP) (1998) Glembotski

Mar 8 MAP Kinases
Ca Signaling Ostrom & Insel (1999)*
Schlegel et al. (1998)Ý
Okamoto et al. (1998)Ý
Anderson (1998)Ý
Meldolesi (1998)*
Rybin et al. (1999)*
* or * = required reading
Ý = highly recommended reading Glembotski
McDonough

Mar 15 Ca Signaling
Ca Signaling Li et al (1998) Nature 392:936*
Dolmetsch et al. (1997) Nature 386:855* McDonough

Mar 22 Ca Signaling
Apoptosis Dolmetsch et al. (1998) Nature 392:933
Budihardjo et al. (1999)
Tsujimoto & Shimizu (2000)
Thress et al (1999) J. Bioenergetics &
Biomembranes 31:321-326 (pdf unavailable)
Ledgerwood et al. (1999) Lab. Invest. 79:1041-1050 (pdf unavailable) McDonough
Sabbadini

Mar 29 Apoptosis
Sphigolipid Signaling Haunstetter & Izumo. (2000) Apoptosis Review
Fujio et al. (1999)
Okamura et al. (2000)
Hannun and Luberto (2000) (see Dr. G for copy)
Lynch and Im (2000) (see Dr. G for copy)
Sabbadini

Apr 5 Sphigolipid Signaling
NFkB Menq-Jer et al (1999) Cell 99: 301-12
(see Dr. G for copy)
Verma & Stevenson.(1997) NFkB Review
May & Ghosh (1998) NFkB Review Sabbadini
Craig

Apr 12 NFkB Li et al.(1999)
Kwak et al (2000) Craig

Apr 19 Spring Break Virtual Paper Abstracts Due 4/26/00

Apr 26 NFkB Haegeman et al. (1998)
Haegeman et al. (1999)
Craig et al. (2000) Craig

May 3 Virtual Paper Help Session Virtual Paper Introduction, Methods and
a Results "Story Board" Due 5/3/00 Glembotski

May 10 Virtual Paper Presentations Glembotski

May 17 Virtual Paper Presentations
Glembotski

May 24 Final Exam 7-9 p.m.
Glembotski
McDonough
Sabbadini
Craig

Date	Topic	Reading	Instructor
Feb 2	Course Organization Introduction, Background Nuclear Receptors	Lodish "MCB" 4th ed. Ch. 20 Schenk (1999) Whitfield et al. (1999) J. Cell. Biochem. Supp. 32/33:110-122	Glembotski
Feb 9	Nuclear Receptors (non-genomic actions)	Watson (1999) Verry (1999) Funder (1999) Tumlin et al. (1997) Santillan & Boland (1998)	Glembotski
Feb 16	Nuclear Receptors G-proteins	Christ et al. (1999) Benitah & Vassort (1999) Chen et al. (1999) Bohm (1997) Mayor et al. (1998)	Glembotski
Feb 23	G-proteins MAP Kinases	Claing (2000) Lin (1997) Paul (1997) Sprague (1998) Whitmarsh (1998) Whitmarsh (1999) Garrington (1999) Ono (2000)	Glembotski
Mar 1	MAP Kinases	Luttrell (1999) Whitmarsh (JIP) (1998)	Glembotski
Mar 8	MAP Kinases Ca Signaling	Ostrom & Insel (1999)* Schlegel et al. (1998)Ý Okamoto et al. (1998)Ý Anderson (1998)Ý Meldolesi (1998)* Rybin et al. (1999)* * *or = required reading Ý = highly recommended reading**	Glembotski McDonough
Mar 15	Ca Signaling Ca Signaling	Li et al (1998) Nature 392:936* Dolmetsch et al. (1997) Nature 386:855*	McDonough
Mar 22	Ca Signaling Apoptosis	Dolmetsch et al. (1998) Nature 392:933 Budihardjo et al. (1999) Tsujimoto & Shimizu (2000) Thress et al (1999) J. Bioenergetics & Biomembranes 31:321-326 (pdf unavailable) *Ledgerwood et al. (1999) Lab. Invest.* 79:1041-1050 (pdf unavailable)**	McDonough Sabbadini
Mar 29	Apoptosis Sphigolipid Signaling	Haunstetter & Izumo. (2000) Apoptosis Review Fujio et al. (1999) Okamura et al. (2000) Hannun and Luberto (2000) (see Dr. G for copy) Lynch and Im (2000) (see Dr. G for copy)	Sabbadini
Apr 5	Sphigolipid Signaling NFkB	Menq-Jer et al (1999) Cell 99: 301-12 (see Dr. G for copy) Verma & Stevenson.(1997) NFkB Review May & Ghosh (1998) NFkB Review	Sabbadini Craig
Apr 12	NFkB	Li et al.(1999) Kwak et al (2000)	Craig
Apr 19	Spring Break	Virtual Paper Abstracts Due 4/26/00
Apr 26	NFkB	Haegeman et al. (1998) Haegeman et al. (1999) Craig et al. (2000)	Craig
May 3	Virtual Paper Help Session	Virtual Paper Introduction, Methods and a Results "Story Board" Due 5/3/00	Glembotski
May 10	Virtual Paper Presentations		Glembotski
May 17	Virtual Paper Presentations		Glembotski
May 24	Final Exam 7-9 p.m.		Glembotski McDonough Sabbadini Craig