The Impact of Genomics on Drug Discovery
Functional Genomics and Pharmacology - Agenda for Today -
The Human Genome Project
The Human Genome Project - Timelines -
The Human Genome Project - Achievements -
The Human Genome Project - What’s Next? -
Paradigm Shifts in Drug Discovery - Product of the Genomics Revolution -
The Original Approach to Drug Discovery - Pharmacology-to-Protein -
The Semi-Original Approach to Drug Discovery - Protein-to-Gene -
A New Paradigm for Drug Discovery - Gene-to-Function -
Productivity Gaps Facing Drug Discovery Programs
Productivity Gaps Facing Drug Discovery Programs - Why do Drugs Fail? -
What are the new challenges for drug discovery as a result of the genomics revolution?
Drug Discovery in the Genomic Age - Changing Bottlenecks -
Productivity Gaps Facing Drug Discovery Programs - Genomics to the Rescue? -
Target Validation Approaches
Comparative Genomics
DNA Microarrays
Advances in RNA Analytics has Resulted in Marked Increases in Information Obtained Per Experiment
DNA Microarrays - Mechanics -
General Overview of cDNA Microarray Process
Visualization of Fluorescence Microarrays
PPT Slide
DNA Array Analysis of Drug Treated Cells
DNA Microarrays - Limitations -
Proteomics I
Sequence motifs for some of the common co- and post-translational modifications. Amino acids in italics are those that will be modified in each case
Proteomics II
Proteomics III
2-Dimensional Gel Electrophoresis
Protein Analysis Based on 2-D Gel Technology
Proteomics - Limitations -
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