Vesicular Mitochondrion in an Apoptotic HeLa Cell

Author: T. G. Frey

Vesicular Mitochondria have unergone a transformation from the normal morphology with an inner boundary membrane connected to lamellar cristae via crista junctions into a form with multiple vesicular matrix compartments. This facilitates membrane fission or fragmentation as the matrix is fragmented at this stage, so fragmentation of the mitochondrion requires only outer membrane fission. Vesicular mitochondria begin to appear during the release of cytochrome c initiating apoptosis.