Normal/Vesicular Mitochondrion in an Apoptotic HeLa Cell

Author: T. G. Frey

Normal/Vesicular mitochondria are in the process of a dramatic transformation from normal morphology with an inner boundary membrane closely apposed to the outer membrane connected to lamellar crista compartments via circular crista junctions. In this example the normal morphology with cristae rendered in green and surrounded by an inner boundary membrane rendered in white/gray appears at one end, while at the other end the inner membrane has transformed into numerous vesicular matrix compartments. Mitochondria in this class begin to appear during the release of cytochrome c from mitochondria initiating apoptosis.