PERL has offices at SDSU in the North Life Sciences Building (Rooms 201, 201B, 239, & 239A), a greenhouse on Alvarado Ct. (just east of SDSU), and an adjacent support laboratory ("the oyster").

PERL operates two outdoor mesocosm facilities at the Tijuana River National Estuarine Research Reserve (301A Caspian Way, just east of the Tijuana Estuary Visitor Center). The tidal area has 24 tidally-flushed mesocosms, each 1x10m, with gates to modify tidal inflow and plumbing to deliver freshwater in controlled amounts. A nearby upland propagation area has 20 2-m2 mesocosms and 18 1-m2 mesocosms that are used in plant propagation experiments.

PERL scientists have expertise with coastal vegetation, invertebrates, fish, and birds. They currently study Tijuana Estuary, Sweetwater Marsh National Wildlife Refuge, San Diego River Estuary, wetlands of Mission Bay and Famosa Slough, Los Peñasquitos Lagoon, and San Elijo Lagoon.

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